Scientists who found life-saving Covid drug aim to find flu cure

Scientists who found life-saving Covid drug aim to find flu cure

November 29, 2022

Are we on the brink of a cure for FLU? Scientists who found life-saving Covid drug aim to test medicine that could save Britons from influenza

  • Trials at 150 NHS hospitals will take place over the next two years and test drugs
  • Flu cases set to soar this year as immunity down after two years of lockdowns
  • The £2.9 million REMAP-CAP trial will now work with the NIHR to run the testing

Scientists who found a Covid treatment that saved thousands of lives have now set their sights on curing flu.

Trials at 150 NHS hospitals will take place over the next two years and test drugs on thousands of flu-infected Brits.

Flu cases could rocket this year, experts have warned, as immunity to the virus has gone down after two years of lockdowns.

The £2.9 million REMAP-CAP trial, originally set up to tackle pandemic, will now work with the National Institute for Health and Care Research (NIHR) to run the testing.

Scientists who found a Covid treatment that saved thousands of lives have now set their sights on curing flu

Trials at 150 NHS hospitals will take place over the next two years and test drugs on thousands of flu-infected Brits

Their 2021 work proved that the arthritis drug tocilizumab could help get rid of the risk of Covid death by more than a third.

Doctors around the world began using the medicine right away.

While many people with flu get better on their own without needing hospital treatment, it can make some seriously ill and even be life-threatening.

There is no clear evidence about which treatments are best for severe cases.

This is the first time a trial of this kind will be used for flu.

The trial is designed to provide answers quickly by using a rapid approach to test multiple treatments at the same time in thousands of people.

The nature of the trial will allow the team to ensure people are given treatments that show encouraging results as soon as possible.

Professor Anthony Gordon, chief investigator of the new trial, from Imperial College London’s Department of Surgery and Cancer, said: ‘During the pandemic, our trial was able to rapidly respond to a new virus and our approach helped save lives.

‘We’re now redeploying it against a known threat.

Minister for Health and Secondary Care Will Quince (UK PArliament/PA)

‘Flu is very infectious and can make children, the elderly and vulnerable people seriously unwell in some cases.

‘This winter, we might see more flu cases than usual as the virus potentially resurges after pandemic measures have kept levels low.

‘We hope that our trial will help to find urgently needed flu treatments rapidly.

‘Our Covid-19 trial changed clinical practice globally, and we hope we can impact flu treatment and reduce winter pressures on the NHS in the same way.’

Running for two years (in the first instance), the trial aims to recruit several thousand people, and will test multiple treatments.

These include the anti-viral treatments oseltamivir (also known as Tamiflu) and baloxavir, as well as steroids and anti-inflammatory drugs that were found to be effective against Covid.

The trial will be open to adults, children, and babies over the age of one month who are in hospital with severe flu.

Dr Elizabeth Whittaker, a consultant in paediatric infectious diseases at Imperial College Healthcare NHS Trust, said: ‘Flu can be a very serious illness for some children, in some cases leading to hospitalisation and problems like bronchitis and pneumonia.

‘Getting the free spray flu vaccine is our first line of defence and drastically reduces the risks for children. But we also need more treatments to help those children who do become very ill, which is why this trial is so important.

‘Working with a range of experts across the country, we hope to determine the best treatments for flu and ultimately save lives.’

The trial is designed to provide answers quickly by using a rapid approach to test multiple treatments at the same time in thousands of people

Minister for Health and Secondary Care Will Quince, said: ‘Clinical research was vital in our fight against Covid and helped to save thousands of lives across the country.

‘This innovative trial will use the lessons we learned from Covid and deliver treatments to reduce serious illness in patients with flu, ease pressure on the NHS and ultimately save lives.’

The researchers will study how effective the treatments are at reducing deaths from flu and stopping patients needing intensive care.

The trial will be run by researchers and clinicians from Imperial College London and Imperial College Healthcare NHS Trust in collaboration with other national experts.

It is funded by the NIHR and delivered by the NIHR’s Clinical Research Network.

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